Rrm2 molecular weight

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August undefined, 2024

WebNov 8, 2024 · To gain insights into this we assayed the binding affinities of SETD2 fragments to hnRNP L by performing isothermal titration calorimetry (ITC). The results showed that SETD2 2167–2192 binds to... WebRRM2-specic inhibitors such as hydroxyurea or the more potent compound triapine (alias 3-AP) [9]. 6, ... Tumour growth on time course and h Tumour weight at the experimental endpoint. Arrows indicate treatment start. Values were normalized to Dox (–). Horizontal bars represent means and whiskers SEM. FC, fold change. P‑values were

Novel chimeric transcript RRM2-c2orf48 promotes metastasis in ...

WebMar 14, 2014 · For RRM2 and RRM2c, each GdnHCl titration sample was excited at 274 nm, and tyrosine emission spectra were collected from 280 to 400 nm at 20 or 37 °C with 5-nm slit widths. WebDec 28, 2024 · The coding region of RRM2 comprises 1,170 nucleotides, which codes a protein of 389 amino acids with a calculated molecular mass of 44,883 Da. 11 The amino … cyber awareness training hack

Identification of CKS2 and RRM2 as potential markers of

WebJan 5, 2024 · This study was performed by investigating RRM2 protein expression in breast cancer and correlating the results with other clinicopathological variables using … WebCalculated molecular weight: 389 aa, 45 kDa: Observed molecular weight: 45 kDa: GenBank accession number: BC030154: Gene symbol: RRM2: Gene ID (NCBI) 6241: Conjugate: … WebThe encoded protein has a calculated molecular weight of 47 kDa and contains four phosphorylation sites (serine at 366 and threonine at residues 302, 362, and 389) located at the C-terminal [2]. cyber awareness training ft. gordon

BRCA1-regulated RRM2 expression protects glioblastoma cells

Ribonucleotide reductase small subunit M2 is a master …

WebRecombinant Human RRM2 protein (ab99137) Datasheet SDS Submit a review Submit a question $275 Product size 100 µg $275 500 µg $1,035.00 Add to basket Order now and … WebRecombinant Human RRM2 His Protein. Backed by our 100% Guarantee. Skip to main content. Items in Cart (0) Quick Order . COVID-19 Research Tools ... The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other ... cheap hotels jacksonville beach floridaWebWe refined the RRM2 signature by integrating it with two molecular classification systems (PCS and PAM50 subtypes) that define aggressive PC subtypes (PCS1 and luminal B) … cheap hotels jefferson city

"WebFeb 28, 2009 · The human RRM2 gene specific siRNA (sc-36338) and scramble siRNA were purchased from Santa Cruz Biotechnology, Inc. (Santa Cruz, CA). 5 × 10 5 /well KB cells were cultured in six-well plates with 2-mL antibiotic-free growth medium at 37°C in a CO 2 incubator for 24 hours. siRNA duplex-Lipofectamine was prepared by 6.0 μL of 10 μmol/L … " - Rrm2 molecular weight

Rrm2 molecular weight

Ribonucleotide reductase M2 (RRM2): Regulation, function and …

WebMar 21, 2024 · RRM2 (Ribonucleotide Reductase Regulatory Subunit M2) is a Protein Coding gene. Diseases associated with RRM2 include Diamond-Blackfan Anemia 20 and Choriocarcinoma. Among its related pathways are pyrimidine deoxyribonucleotides … Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis … Molecular mass: 13903 Da Protein existence level: PE1 Quaternary structure: … ABCB1 (ATP Binding Cassette Subfamily B Member 1) is a Protein Coding gene. … RBMX (RNA Binding Motif Protein X-Linked) is a Protein Coding gene. Diseases … Ataxia-telangiectasia (A-T) is a recessive disorder resulting from germline … CFTR (CF Transmembrane Conductance Regulator) is a Protein Coding gene. … Size: 882 amino acids Molecular mass: 97456 Da Protein existence level: PE1 … MAPK1 (Mitogen-Activated Protein Kinase 1) is a Protein Coding gene. Diseases … NTRK1 (Neurotrophic Receptor Tyrosine Kinase 1) is a Protein Coding gene. … HMGB1 (High Mobility Group Box 1) is a Protein Coding gene. Diseases … WebMolecular Weight (Da) 389. 44878. Protein Name. Ribonucleoside-diphosphate reductase subunit M2. Sources. UniProt. PhosphoSitePlus ®. GeneCards.

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WebKey features and details Mouse monoclonal [1E1] to RRM2 Suitable for: WB, IHC-P, ICC/IF, Flow Cyt Reacts with: Human Isotype: IgG1 You may also be … WebRRM2 is a new molecular marker for the diagnosis and clinical outcomes of cervical cancer. It is involved in cervical carcinogenesis and predicts poor survival. these findings suggest …

WebMar 15, 2024 · Highly expressed RRM2 is associated with poor OS and DMFS of breast cancer patients. Furthermore, the high expression of RRM2 was associated with poor OS in breast cancer patients characterized by specific molecular subtypes (Luminal A subtype and Normal-like subtype) and specific stages (stage 1 and stage 2). WebSep 14, 2024 · The molecular weight of the chimeric protein was slightly lower than that of the wild-type RRM2 (45 kd) ( ). Thus, the chimeric RRM2-c2orf48 may function through its translated protein, which may be an attractive candidate as a useful biomarker for NPC. RRM2-c2orf48 expression in cell line and NPC specimen protein levels

WebMar 21, 2024 · Size: 2752 amino acids Molecular mass: 299615 Da Protein existence level: PE1 Quaternary structure: Component of pre-catalytic, catalytic and post-catalytic spliceosome complexes (PubMed:11991638, 28502770, 28076346, 29361316, 29360106, 29301961, 30705154). Found in a pre-mRNA splicing complex with SFRS4, SFRS5, … WebJul 7, 2024 · The RRM2 mRNA levels were significantly upregulated by 2.2–5.6-fold in cancerous vs. normal tissues, while the mRNA levels of RRM1 and RRM2B were changed less in these studies (Fig. 1A ).

WebOct 23, 2024 · The analysis revealed that SC35 attaches to certain parts of a large, flexible protein called SRRM2. Ilik et al. discovered that although the structure and sequence of …

WebTargeted protein degradation (TPD) holds immense promise for drug discovery, but mechanisms of acquired resistance to degraders remain to be fully identified. Here, we used clustered regularly interspaced short palindromic repeats (CRISPR)-suppressor scanning to identify mechanistic classes of drug resistance mutations to molecular glue degraders in … cheap hotels jaco beach costa ricaWebSep 13, 2016 · RRM2 is rate-limiting for the conversion of NTPs into dNTPs during the S-phase of the cell cycle ( 11 ). RRM2 is highly upregulated in melanoma cells harboring mutant BRAF V600E, and high RRM2 expression correlates with worse overall survival of patients with melanoma ( 12 ). cyber awareness training jeffWebJul 13, 2024 · RRM2 is the catalytic component of the RNR enzyme and is essential for the maintenance of deoxynucleotide triphosphate (dNTP) pool homeostasis required for DNA replication and repair. Synthesis of RRM2 protein is regulated in a cell cycle–dependent fashion, increasing to maximal levels during S phase of the cell cycle ( 10 – 12 ). cyber awareness training level 1WebAug 12, 2024 · RRM2 Background Ribonucleotide reductase catalyzes the formation of deoxyribonucleotides from ribonucleotides. It is composed of 2 non-identical subunits, … cyber awareness training mylearningWebRRM2. Status. UniProtKB reviewed (Swiss-Prot) Organism. Homo sapiens (Human) Amino acids. 389. Protein existence. Evidence at protein level. Annotation score. 5/5. Entry. ... Molecular Function: ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor Source:UniProtKB. cyber awareness training loginWebDec 28, 2024 · RNR consists of two subunits: the large subunit ribonucleotide reductase M1 (RRM1) and the small subunit (RRM2 or RRM2B). Interestingly, RRM2 is generally highly expressed in cancers [ 15 ]. It has been demonstrated that the overexpression of RRM2 is associated with drug and chemotherapy resistance [ 16, 17 ]. cyber awareness training linkWebMay 1, 2024 · RRM2 knockdown promoted the degradation of CDK1 protein through autolysosome-dependent pathway by increasing autophagic flow, thereby inhibiting the proliferation of glioblastoma by inducing G2/M... cyber awareness training fort gordon army