Web12 aug. 2024 · Eliciting regulated cell death, like necroptosis, is a potential cancer treatment. However, pathways eliciting necroptosis are poorly understood. It has been reported that prolonged activation of acid-sensing ion channel 1a (ASIC1a) induces necroptosis in mouse neurons. Glioblastoma stem cells (GSCs … Web22 jul. 2014 · In conclusion, we have shown that the cytoplasmic N-terminal domain of MSL10 is capable of inducing cell death, that this activity is regulated by …
Ion channels in regulated cell death Request PDF - ResearchGate
WebCyclic nucleotide-gated ion channels have been identified in animals and plants. However, the physiological role of these ion channels in plant cells and in non-receptor cells of … Web13 apr. 2024 · This includes ion channels, exchangers, transporters, and G protein-coupled receptors. Functional alterations of these proteins may induce a disease state in human. The project focus on the leak sodium channel NALCN. NALCN plays a crucial role in excitability of neurons and endocrine/neuroendocrine cells mary june roberts
Developmentally regulated expression of a cyclic nucleotide-gated …
WebIon channels in regulated cell death Published in: Cellular & Molecular Life Sciences, April 2016 DOI: 10.1007/s00018-016-2208-z: ... Karl Kunzelmann Abstract: Activation of ion channels and pores are essential steps during regulated cell death. Channels and pores participate in execution of apoptosis, necroptosis and other forms of caspase ... Web1 aug. 2024 · There are several forms of regulated cell death (RCD) that use lipids as key parts of cell death pathways, ... Ion homeostasis, channels, and transporters: an update on cellular mechanisms. Adv. Physiol. Educ., 28 (2004), pp. 143-154. CrossRef View in Scopus Google Scholar. 35. Web7 mrt. 2024 · Caspase-3 is a key protein commonly found in the pathways of apoptosis and pyroptosis and is a bridge connecting the two modes of death, apoptosis and coking death. Apoptosis consists of endogenous and exogenous pathways. Both internal and external apoptosis signals can activate the caspase protein and initiate programmed death. mary jungwirth