WebNov 21, 2024 · Methods: In this phase 3, placebo-controlled trial, we randomly assigned 4744 patients with New York Heart Association class II, III, or IV heart failure and an ejection fraction of 40% or less to receive either dapagliflozin (at a dose of 10 mg once daily) or placebo, in addition to recommended therapy. The primary outcome was a composite … WebNov 8, 2024 · Insulin-like growth factor–binding protein-7 (IGFBP-7) is a potential prognostic marker in heart failure. Adjusted hazard ratio for the primary endpoint for tertile 3 vs. …
Dapagliflozin in Patients With Heart Failure and Reduced Ejection ...
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Advances in Clinical Trials
WebFeb 28, 2024 · The DAD-HF II trial investigated differences in all-cause mortality or heart failure hospitalizations between three separate groups: high-dose furosemide (20 mg/h), low-dose furosemide (5 mg/h) with low-dose dopamine (5 μg/kg/min), and low-dose furosemide alone . WebThe Dopamine in Acute Decompensated Heart Failure II (DAD-HF II) trial showed similar clinical efficacy of (a) high-dose furosemide (20 mg/h for 8 h), (b) low-dose furosemide (5 mg/h for 8 h), and (c) low-dose furosemide combined with low-dose dopamine (5 μg/kg/min) in 161 randomised patients hospitalised for acute decompensated heart failure ... WebDec 14, 2024 · The Dopamine in Acute Decompensated Heart Failure (DAD-HF) trial confirmed for AHF patients on high dose furosemide (20mg/h continuous for 8 h), the incidence of WRF was obviously higher than those on low dose furosemide combined with low dose dopamine (furosemide 5 mg/h plus dopamine 5 mg·kg −1 ·min −1 continuous … scripture about giving thanks in all things