Cisplatin koordinationszahl

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August undefined, 2024

WebThe optimal cumulative dose and timing of cisplatin administration in various concurrent chemoradiotherapy protocols for nonmetastatic head and neck squamous cell carcinoma … Webappropriate concentration, while cisplatin (Ebewe Pharma, Unterach, Austria) was given undiluted. The administered volumes for cisplatin and cefepime ranged from 0.3 to 0.91 ml and from 0.3 to 0.35 ml, respectively. Experimental procedure Cisplatin was administered in 10, 14, 18, 22 and 26 mg/kg doses; the control group received saline.

Cisplatin - an overview ScienceDirect Topics

WebCisplatin has shown activity against osteosarcoma, transitional cell carcinoma, squamous cell carcinoma (SCC), melanoma, mesothelioma, carcinomatosis and germinal cell tumours in the dog. In the cat, cisplatin cannot be utilized because of fulminant pulmonary oedema that occurs at standard doses. Web1152 rows · Jun 13, 2005 · Cisplatin is a platinum based chemotherapy agent used to … shangri la hotel reservations

Stereoisomers: Geometric Isomers in cis-platin - Chemistry …

WebFeb 17, 2024 · Cisplatin: Urine (13% to 17% within 1 hour); Platinum: Urine (35% to 51%) Half-Life Elimination Children: Free drug: 1.3 hours; Total platinum: 44 hours Adults: Cisplatin: 20 to 30 minutes; Platinum: ≥5 … WebNational Center for Biotechnology Information WebCisplatin for injection has been administered at 75 mg/m. 2 . to 100 mg/m. intravenously per cycle once every 3 to 4 weeks on Day 1. Other doses and combination regimens have been used. 2.4 Advanced Bladder Cancer . Cisplatin for injection has been administered at 50 mg/m. 2 . to 70 mg/m. intravenously per cycle once every 3 to 4 weeks. poly ethylene dichloride

Cisplatin 1 mg/ml Sterile Concentrate - Summary of Product ...

Current Strategies to Combat Cisplatin-Induced …

Web(a) The structure of cisplatin (with platinum shown in green and nitrogen ligands shown in blue) coordinated to a dinucleotide containing two guanines. Notice the destacking of guanine bases, which would normally be parallel to one another. (b) The structure of cisplatin coordinated to two guanines in a DNA duplex. Reprinted with permission.1 WebJun 13, 2005 · Following cisplatin doses of 20 to 120 mg/m^2, the concentrations of platinum are highest in liver, prostate, and kidney; somewhat lower in bladder, muscle, testicle, pancreas, and spleen; and lowest in bowel, adrenal, heart, lung, cerebrum, and cerebellum. Platinum is present in tissues for as long as 180 days after the last … shangri-la hotels and resorts groupWebSep 18, 2024 · Cisplatin is a medication used to manage and treat solid tumors and hematologic malignancies. It is in the alkylating agent class of cytotoxic medications. This activity reviews the indications, action, and … shangri la hotel resorts

"WebCisplatin, a class of platinum-containing anticancer drugs for the treatment of solid tumors, is a substrate of OCT2 and MATE1/MATE2-K. OCT2 is expressed in the basolateral membrane of proximal tubules and mediates the transport of cisplatin from the blood to proximal tubule cells. " - Cisplatin koordinationszahl

Cisplatin koordinationszahl

Cisplatin 12. Modes of Action of Cisplatin - Chemistry LibreTexts

WebCisplatin. Cisplatin is a chemotherapy drug. You might have it as a treatment for a number of different types of cancer. You might have cisplatin on its own or in combination with … WebFeb 16, 2024 · Generic name: cisplatin [ sis-PLA-tin ] Brand names: Platinol, Platinol-AQ, Platinol (Restricted Access) Dosage forms: intravenous powder for injection (50 mg), …

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WebMar 29, 2024 · Reviewed on 3/29/2024. Cisplatin: An anticancer drug that belongs to the family of drugs called platinum compounds. Cisplatin is used in the treatment of a wide … WebMedscape - Cancer dosing for Platinol, Platinol AQ (cisplatin), frequency-based adverse effects, comprehensive interactions, contraindications, pregnancy & lactation schedules, and cost information. News & Perspective

WebMaterial Name: Cisplatin Solution for Injection - 0.5 and 1 mg/ml Revision date: 02-Jan-2007 Page 7 of 7 Version: 1.1 16. OTHER INFORMATION Reasons for Revision: Updated Section 2 - Composition / Information on Ingredients. Updated Section 3 - Hazard Identification. Updated Section 5 - Fire Fighting Measures. WebCisplatin is a chemotherapy drug used to treat testicular, ovarian, bladder, head and neck, lung and cervical cancer. It may also be used to treat other cancers. It is best to read this information with our general information about chemotherapy and the …

Cisplatin (cis-Diammindichloridoplatin; DDP) ist ein Arzneistoff (Zytostatikum zur Hemmung des Zellwachstums bzw. der Zellteilung) und enthält ein komplexgebundenes Platinatom. Die Wirkung beruht auf einer Hemmung der DNA-Replikation durch Querverknüpfungen zweier benachbarter … See more Cisplatin wurde zuerst 1844 von Michele Peyrone synthetisiert, damals bekannt als Peyrones Chlorid. Es spielte eine Rolle bei der Entwicklung der Komplexchemie durch Alfred Werner. Die Entdeckung der zytostatischen … See more Wirkungsmechanismus Cisplatin wirkt ähnlich wie bifunktionelle Alkylantien durch Querverknüpfungen von DNA-Strängen. Der stark elektrophile Aqua-Cisplatin … See more • Markus Galanski, Bernhard K. Keppler: Tumorhemmende Metallverbindungen. In: Pharmazie in unserer Zeit 35(2), S. 118–122 (2006), See more Cisplatin stellt einen planaren Komplex dar, der am zentralen Platinatom zwei cis-ständige Chloridliganden und zwei Amminliganden … See more Monopräparate Cis-GRY (D), Platiblastin (CH), Platinol (CH), zahlreiche Generika (D, A, CH). See more WebOct 22, 2024 · Cisplatin is an alkylating agent which induces DNA damage through the formation of cisplatin-DNA adducts, leading to cell cycle arrest and apoptosis. In the management of advanced OSCC, cisplatin-based chemotherapy or chemoradiotherapy has been considered as the first-line treatment.

Webof cisplatin with urine from healthy subjects, except that the proportions are different. The parent compound, cisplatin, is excreted in the urine and accounts for 13% to 17% of the dose excreted within one hour after administration of 50 mg/m2. The mean renal clearance of cisplatin exceeds creatinine clearance and is 62 and

Webof cisplatin with urine from healthy subjects, except that the proportions are different. The parent compound, cisplatin, is excreted in the urine and accounts for 13% to 17% of the … polyethylene fabric door matWebJul 3, 2024 · Cisplatin is widely used for the treatment of a number of solid malignant tumors. However, ototoxicity induced by cisplatin is an obstacle to effective treatment of tumors. The basis for this toxicity has not been … shangri-la hotel paris priceWebFeb 25, 2024 · The IC 50 value of cisplatin against HeLa cells is 10–20 μM, which is usually determined with an incubation time of 48 h or longer with cisplatin. 39 Thus, we observed that there were still sufficient living HeLa cells after 24 h … polyethylene film 6 milWebJun 29, 2024 · A total of 182 control and 179 cisplatin-treated cells were sequenced. Principal component analysis of expression magnitudes across all cells and genes revealed 7 distinct cell clusters. These clusters are represented in a t -distributed stochastic neighbor embedding ( t -SNE) plot to simplify their visualization ( Figure 2C ). polyethylene epdm tank suppliesWebMaterial Name: Cisplatin Solution for Injection - 0.5 and 1 mg/ml Revision date: 02-Jan-2007 Page 7 of 7 Version: 1.1 16. OTHER INFORMATION Reasons for Revision: … polyethylene film extrudersWebApr 22, 2024 · This work shows a new mechanism of cisplatin resistance in cancer caused by a commonly amplified gene,” Lin said. “Importantly, we identified panobinostat, an HDAC inhibitor, as a potential therapeutic … polyethylene film suppliersWebOct 22, 2024 · A global proteomic profiling of cisplatin-sensitive and cisplatin-resistant OSCC cell lines showed CMTM6 was the top-ranked upregulated protein in cisplatin … shangri la hotels borneo orangutans